Lions vs. Eagles forecast, odds, NFL week 11 picks

The Detroit Lions and Philadelphia Eagles meet in Week 11 in one of the the most intriguing NFC matchups of the season. It will feature two explosive offenses, a physical defense and playoff implications that could shape the conference standings. Detroit continues to establish itself as a legitimate contender behind its brutal run game and aggressive playmaking. Meanwhile, Philadelphia remains one of the toughest teams in the NFC. That’s thanks to his elite quarterback play and a front week that consistently disrupts opposing game plans. With both teams capable of scoring goals and dictating the tempo, Week 11 has all the makings of a high-stakes chess match.

Lions vs. Eagles odds

lions: +2.5, +124
Eagles: -2.5, -148
More: 46.5, -118
Less: 46.5, -102

(All chances thanks DraftKings)

Key injuries for Lions vs. Eagles for Week 11

Lyons: CB Terrion Arnold (concussion) out, S Kerby Joseph (knee) out, TE Sam LaPorta (back) is out,
DE Joshua Paschal (back) out, DE Marcus Davenport (shoulder) questionable

Eagles: G/C Willie Lampkin (knee/ankle) questionable

Lions vs Eagles betting trends

Lions and Eagles have played eight times since 2010. They are 4-4 in those games. The Eagles, however, have won their last two meetings. Entering Week 11, the Eagles had won their last three games, while the Lions had just defeated the Commanders 44-22.

2025 records:

Detroit, 6-3 straight, 6-3 ATS; Philly, 7-2 straight up, 6-3 ATS

More/Less:
Detroit 5-4; Philadelphia, 5-4

Keys to the match Lions vs Eagles

lions:

Campbell takes over the play-calling: After a dominant 44-22 win over the Commanders, the Lions’ offense looks revitalized under head coach Dan Campbell, who has taken over the play-calling duties.

Explosive work: The Lions offense, with a quarterback Jared Goff and running back Jahmir Gibbs, is a high-powered unit that can put up points in a hurry. A foul was scored on every drive and didn’t have a turnover against Washington.

Notice the pedigree: Under Campbell, the Lions were exceptionally composed in nationally televised games. As of this writing, they have a 13-3 record in prime time.

eagles:

Defense force: The Eagles’ defense, bolstered by recent trade acquisitions, poses a significant threat to the Lions’ offense.

A healthy offensive line: Coming off the bye week, the Eagles’ offensive line is in great shape. All starters are expected to be available.

A balanced attack: With the quarterback Jalen Hurts and running back Saquon Barkley leading the charge, the Eagles have a powerful and balanced offense that can control the line of scrimmage.

Lions vs Eagles prediction and pick

Both teams have the offensive firepower to win the shootout. They also have the defensive ability to force momentum-changing plays. The question is who controls the trenches? Philly’s defensive front gives them a slight advantage. This is especially true if they can generate consistent pressure and push Detroit into long situations.

Detroit will keep this close. They probably have a chance late in the game. However, Philadelphia’s combination of quarterback play, scheme versatility and defensive disruption will eventually tip the scales.

Prediction of the final result: Eagles 27, Lions 23
Pick Against the Spread: Eagles -2.5
Over/Under: Over 46.5