Packers vs. Broncos Predictions, Odds, NFL Week 15 Picks

With the NFL playoffs just around the corner and the race for the postseason hotter than ever, we bring you betting predictions and picks for this pivotal Week 15 matchup as Green Bay Packers (9-3-1) visit Denver Broncos (11-2). Check out ours NFL odds series for Packers-Broncos prediction and pick.

The Green Bay Packers lead the NFC North after a 28-21 win over the Chicago Bears in Week 14. The win cemented the Packers as the leaders in the North, but they will still have to play the Bears one more time in addition to this matchup against the best team in the AFC.

The Denver Broncos sit atop the AFC along with the New England Patriots after a 24-17 win over the Las Vegas Raiders. Since starting the season 1-2, the Broncos have won 10 straight games and are currently the hottest team in the NFL hosting the Packers as home underdogs.

NFL odds thanks to DraftKings

Packers vs. Broncos Week 15 Odds

Green Bay Packers: -2.5 (-110)

Denver Broncos: +2.5 (-110)

Over: 42.5 (-110)

Under: 42.5 (-110)

Packers vs. Broncos Key Injuries

*practice status from 12/12/2025*

Green Bay: (DNP): RB Josh Jacobs / (RESTRICTED): S Javon Bullard, DL Brenton Cox Jr., DL Kingsley Enagbare, VR Matthew Golden, RB MarShavn Lloyd, VR Jaiden Reed, OL Zach Tom, DL Lukas Van Ness, LB Kristian Welch, VR Dontaivion Vicks, VR Savion

Denver: (DNP): VR Pat Bryant / (LIMITED): TE Nate Adkins, G Ben Powers

Packers vs. Broncos Betting Trends

• The Denver Broncos are 6-0 at home this season. The Green Bay Packers are 4-1-1 on the road.
• Broncos are 5-8 ATS overall, 3-3 ATS at home. The Packers are 6-7 ATS overall, 2-4 ATS on the road.
• The Broncos are 2-1, 2-1 ATS in their last three against the Packers.
• The total has gone over in seven of Green Bay’s last 10 games.
• The total has been LESS in 10 of the Broncos’ last 15 games.
• Green Bay is 5-1 ATS in their last six December games.
• Denver is 7-2 ATS against their last nine NFC opponents.

Keys to Packers vs. Broncos Matchup

With the Packers fighting for the NFC North and the Denver Broncos looking to secure the AFC crown, this Week 15 matchup proved to be a big one for both teams. Quarterbacks Jordan Love and Bo Nick are arguably the two best in the league right now and their hot streak dates back to the last two months. It’s surprising to see the Packers as road favorites given the Broncos’ success at home this season, but it’s fair to say the Packers have seen a tougher schedule up to this point.

Furthermore, the stats for Jordan Love during November and December are undeniable, and head coach Matt LaFleur boasts 21-4 record at the December games. There is no doubt that they are dealing with significant injuries on both sides of the football – Josh Jacobs missed Thursday’s practice, but LaFleur stressed that he just wants to give his workhorse a rest between weeks. Fortunately, the Packers have RB Emmanuel Wilson as a competent backup option to help keep the game going.

The Denver Broncos are much healthier coming into this game and while their offense, in both passing and running, doesn’t particularly stand out as the best in the NFL, they certainly do enough in both areas to sustain drives and average 23.7 points per game. They are complemented by their defense, which ranks third in the NFL in fewest yards (282.0) per game.

Denver’s front line is great against the run, but so is the Packers’ defensive front behind Mike Parsons. Both teams are effective at stopping the run, so this could be a game where both quarterbacks have an active day. Still, both defenses are two of the best units in the entire league, so don’t be surprised if we see a low-scoring defensive battle.

Packers vs. Broncos Prediction and Pick

With both teams currently playing their best football of the season, this should be the best matchup of Week 15. Both defenses are also at the top of their game, both ranking in the top 5 overall defensive units in the league. Expect long, penetrating runs to be rare during this game, as the intermediate passing game should be a focus for both teams.

At this point, the Packers certainly look like a more dynamic offense with tight end running backs like Josh Jacobs and Jordan Love’s accuracy over the past few games. On the flip side, Bo Nick has proven to be the ultimate game manager for this Bronco team, limiting his conversion errors to 19 touchdown passes this season.

The range is certainly close, but I see the Denver Broncos covering this by the slimmest of margins. I expect the Green Bay Packers to win this game, but Vegas should be right on the money in what I see as a low-scoring, two-point game.

Final Packers-Broncos Week 15 Prediction and Pick: Denver Broncos +2.5 (-110); UNDER 42.5 (-110)